| Title | Macrophages as APC and the dendritic cell myth. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Hume, DA |
| Journal | J Immunol |
| Volume | 181 |
| Pagination | 5829–5835 |
| Date Published | Nov |
| Keywords | Animals, Antigen-Presenting Cells, Biological Markers, Cell Differentiation, Cell Lineage, cytology/immunology/metabolism, Dendritic Cells, genetics/immunology, Humans, Macrophages, metabolism, Mice |
| Abstract | Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied to separate their lineage, pathways of differentiation, and effectiveness in Ag presentation from those of macrophages. This review summarizes evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors (including CSF-1), express the same surface markers (including CD11c), and have no unique adaptation for Ag presentation that is not shared by other macrophages. |
