The chemokine system in diverse forms of macrophage activation and polarization.

TitleThe chemokine system in diverse forms of macrophage activation and polarization.
Publication TypeJournal Article
Year of Publication2004
AuthorsMantovani, A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M
JournalTrends Immunol
Volume25
Pagination677–686
Date PublishedDec
KeywordsAnimals, Cell Differentiation, Chemokine, Chemokines, cytology/immunology, Humans, Immunological, immunology, Macrophage Activation, Macrophages, metabolism, Mice, Models, Monocytes, Receptors, T-Lymphocytes, Terminology as Topic
AbstractPlasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
URLhttp://dx.doi.org/10.1016/j.it.2004.09.015
DOI10.1016/j.it.2004.09.015