June 2013: We have updated the Macrophage Pathways section!
- available in a range of different formats to suit a number of viewing and analysis needs. Take a look here.
May 2013: Macrophage Research Highlights this month. Macrophages and salamander limb regeneration!
- Macrophages and limb regeneration: Macrophages are required for adult salamander limb regeneration. Godwin et al., demonstrate the requirement of macrophage infiltration in the regenerative process in aquatic salamander. See Godwin et al., Proc Natl Acad Sci U S A. 2013 May.
April 2013: Macrophage Research Highlights this month. Blood and Macrophages!
- Macrophages and erythropoiesis: Two papers published in Nature Medicine explore the critical role of macrophages in erythropoiesis. They find macrophages support erythropoiesis under homeostasis, stress, and pathological conditions. See Nature Medicine 2013 Apr, 19(4):429-36 and Nature Medicine 2013 Apr, 19(4):437-45
March 2013: Macrophage Research Highlights this month. The Trib1 with Macrophages!
- Trib1 and macrophage differentiation: Trib1 is critical for the differentiation of a population of tissue-resident macrophages, with consequences for adipose tissue maintenance and metabolic disorders in mice lacking Trib1. Study published in Nature 2013 Mar, 495(7442):524-8
February 2013: Macrophage Research Highlights this month: Dendritic Cells vs Macrophages
- Can DC’s be distinguished from macrophages by molecular signatures? Follow Hume et al’s, commentary on the Immunological Genome Consortiums recent interpretations of transcriptomics data from derived from these cells. Read in Nat Immunol. 2013 Mar, 14(3):187-9 and the authors response in Nat Immunol. 2013 Mar, 14(3):189-90. See also Hume, et al's, analysis of the data on macrophages.com/HumeNI2013
January 2013: Macrophage Research Highlights this month and Happy New Year from macrophages.com
- Happy New Year from the macrophages.com team: Since this a community resource, we’re eager to hear your views on this site, as well as suggestions and contributions for content including news items. Contact us!
- Macrophage JNK and metabolic complications: Han et al., examine the significance of JNK signalling in macrophages in the metabolic response. They show mice with macrophage-specific JNK deficiency are protected against insulin resistance, associated with reduced tissue infiltration by macrophages. See their article: JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation in Science 2013 Jan;339(6116):218-22.
October 2012: What's new at macrophages.com this month:
- Access our network analysis of transcriptional data from the Immunological Genome Project comparing gene expression signatures in different populations of monocytes, macrophages and dendritic cells. Go to the microarray study here.
August 2012: Registeration now open for the EMBO Workshop on Macrophage Biology 17-19 January 2013
Macrophage Workshop 17-19 January 2013 to be held in Marseille, France. Accompanied by 5th Luminy Advanced Course in Immunology (LACI) from 14-19 January. Deadline for registeration: 1 November 2012. For further information and registeration see this flyer and EMBO events page.
May 2012: What's new at macrophages.com this month:
- Find our online review of macrophage biology at: www.macrophages.com/macrophage-review a great starting place to for those want to learn more about this cell and a good read for everyone else.
- Find our pre-analysed network graphs of the gene expression data from the Schulz et al., 2012 study into macrophage relationship to hematopoietic stem cells and yolk sac precursors. Go to the microarray study here.
April 2012: Macrophage Research Highlights This Month! Yolk-sac derived macrophages in adult mice and the crystal structure of IL-34 bound to the CSF-1-receptor.
- Yolk-sac Macrophages: Schulz et al., demonstrate the existence of macrophages derived from the yolk-sac that can persist independently of hematopoietic stem cells (HSCs) and the transcription factor Myb in adult mice, in their paper: A lineage of myeloid cells independent of Myb and hematopoietic stem cells. The findings support the concept of two myeloid systems which overlap and renew independently in mice. Read in Science 2012 Apr 6;336(6077):86-90.
- IL-34-CSF-1-Receptor Structure: Ma et al., reveal the crystal structure of IL-34 bound to the CSF-1-receptor (CSF-1R) in their publication: Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Despite a lack of sequence similarity both CSF-1 and IL-34 signal through the CSF-1R receptor. The authors show this occurs due to unique conformational adaptations in the receptor itself and that the complex architecture of IL-34 bound to the CSF-1R is in fact similar to that of CSF-1/CSF-1R assembly. For more details see: Structure 2012 Apr 4;20(4):676-87.
April 2012: Postdoctoral Research Fellow Job Opening in Macrophage Biology and Lipid Metabolism
....at the Brigham and Women's Hospital and Harvard Medical School, Boston.
- The Centre for Interdisciplinary Cardiovascular Sciences (CICS; Director Masanori Aikawa, MD, PhD) is seeking a postdoctoral fellow for their translational research efforts in macrophage biology and lipid metabolism. For further information see the CICS webpages and their job description.
March 2012: Macrophage Publications Updated!
- See our Publications and Review section; updated for recent macrophage publications of interest!
November 2011: Read All About macrophages.com in the Immunobiology Journal...
- Manuscript describing the efforts behind macrophages.com has been published in an EMDS special issue “Systems Biology of Macrophages and Dentritic Cells in Health and Disease” within the Immunobiology Journal (Volume 216, Issue 11, Pages 1163 – 1238, November 2011). To view the manuscript click here.
July 2011: New Website Launched!
- The brand new version of macrophages.com was launched on 19 July 2011; now incorporating a number of enhancements:
- Enhanced image library navigation
- Enabled content-specific contributions from registered users
- Increased collection of macrophage-relevant microarray datasets
- Additional feature to generate on-the-fly BioLayout Express3D Webstart
- Additional publications with enhanced category-based navigation
- Provision for community-driven comments and feedback
- A Google-powered search functionality - available on the home page