Macrophage pathways

Resources for the Analysis of Macrophage Pathways

Pathway diagrams are visual representations of known interaction networks between cellular components. Modelling pathways is fundamental to our understanding of the workings of biological systems. This resource brings together the currently available pathway-models relevant to signalling within this cell. Including:

• Models derived from our own efforts to depict signalling and effector pathways central to macrophage function (below).
• Other relevant pathway resources available.

Macrophage Pathway Diagrams

The following pathways have been assembled using the modified Edinburgh Pathway Notation (mEPN) scheme. The mEPN is a graphical language for depicting relationships between pathway components.  All pathways were created manually using the free network-diagramming software yEd Graph Editor and are based on published literature. The diagrams undergo a rigorous internal review process to ensure the information portrayed is accurate at time of pathway completion. For full descriptions of the individual pathways follow their relevant links.

The pathways can be accessed in a number of software suited for different needs (follow pathway page links to download appropriate files):

• yEd format (.graphml file). Download yEd Graph Editor (free) and open .graphml file in here for fast viewing, editing, and to access the pathways in their orignal editior and notation (mEPN).
• Biolayout format (.graphml file). Open the .graphml file in BioLayout Express^3D (free) for analysis purposes and overlay of data onto the pathway.
• VANTED/ SBGN-ED format (sbgn file). Download VANTED and SBGN-ED (both free) to open the SBGN compliant version of the pathway.

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Macrophage Activation Pathway Title: Integrated Macrophage Pathways v1 Biolayout webstart:

Macrophage Activation Extended Pathway Title: Integrated Macrophage Pathways v2 Biolayout webstart: