These freely accessible resources relate mainly to macrophages and immunology and are intended for professional colleagues. They require a good general knowledge of cellular biology to interpret.

Macrophage Biology

The macrophage: past, present and future.
Gordon S.
Eur J Immunol. 2007 Nov;37 Suppl 1:S9-17. Review.
PMID: 17972350

The mononuclear phagocyte system.
Hume DA.
Curr Opin Immunol. 2006 Feb;18(1):49-53. Epub 2005 Dec 9. Review.
PMID: 16338128

Apoptotic cell removal in development and tissue homeostasis.
Henson PM, Hume DA.
Trends Immunol. 2006 May;27(5):244-50. Epub 2006 Apr 3. Review.
PMID: 16584921

Macrophage Activation and Polarisation

Exploring the full spectrum of macrophage activation.
Mosser DM, Edwards JP.
Nat Rev Immunol. 2008 Dec;8(12):958-69.
PMID: 19029990

Macrophages as APC and the dendritic cell myth.
Hume DA.
J Immunol. 2008 Nov 1;181(9):5829-35.
PMID: 18941170

Macrophage activation and polarization.
Martinez FO, Sica A, Mantovani A, Locati M.
Front Biosci. 2008 Jan 1;13:453-61. Review.
PMID: 17981560

New vistas on macrophage differentiation and activation.
Mantovani A, Sica A, Locati M.
Eur J Immunol. 2007 Jan;37(1):14-6. Review.
PMID: 17183610

Macrophage activation by endogenous danger signals.
Zhang X, Mosser DM.
J Pathol. 2008 Jan;214(2):161-78. Review.
PMID: 18161744

The chemokine system in diverse forms of macrophage activation and polarization.
Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M.
Trends Immunol. 2004 Dec;25(12):677-86. Review.
PMID: 15530839

Alternative activation of macrophages.
Gordon S.
Nat Rev Immunol. 2003 Jan;3(1):23-35. Review.
PMID: 12511873

Monocyte and macrophage heterogeneity.
Gordon S, Taylor PR.
Nat Rev Immunol. 2005 Dec;5(12):953-64. Review.
PMID: 16322748

Macrophage Transcription

Systems biology of transcription control in macrophages.
Ravasi T, Wells CA, Hume DA.
Bioessays. 2007 Dec;29(12):1215-26. Review.
PMID: 18008376

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis.
Bonifer C, Hume DA.
Front Biosci. 2008 Jan 1;13:549-60. Review.
PMID: 17981568

Transcriptional regulatory networks in macrophages.
Hume DA, Wells CA, Ravasi T.
Novartis Found Symp. 2007;281:2-18; discussion 18-24, 50-3, 208-9. Review.
PMID: 17534062

Transcriptional network dynamics in macrophage activation.
Nilsson R, Bajic VB, Suzuki H, di Bernardo D, Björkegren J, Katayama S, Reid JF, Sweet MJ, Gariboldi M, Carninci P, Hayashizaki Y, Hume DA, Tegner J, Ravasi T.
Genomics. 2006 Aug;88(2):133-42. Epub 2006 May 12.
PMID: 16698233

Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks.
Sharma SM, Hu R, Bronisz A, Meadows N, Lusby T, Fletcher B, Hume DA, Cassady AI, Ostrowski MC.
Crit Rev Eukaryot Gene Expr. 2006;16(3):253-77. Review.
PMID: 17073554

Macrophage-specific gene expression: current paradigms and future challenges.
Greaves DR, Gordon S.
Int J Hematol. 2002 Jul;76(1):6-15. Review.
PMID: 12138897

Macrophage Signalling

Signal integration between IFNgamma and TLR signalling pathways in macrophages.
Schroder K, Sweet MJ, Hume DA.
Immunobiology. 2006;211(6-8):511-24. Epub 2006 Jul 5. Review.
PMID: 16920490

Inflammation suppressor genes: please switch out all the lights.
Wells CA, Ravasi T, Hume DA.
J Leukoc Biol. 2005 Jul;78(1):9-13. Epub 2005 Mar 17. Review.
PMID: 15774547

Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins.
Dalpke A, Heeg K, Bartz H, Baetz A.
Immunobiology. 2008;213(3-4):225-35. Epub 2007 Nov 28. Review.
PMID: 18406369

Macrophage receptors and immune recognition.
Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S.
Annu Rev Immunol. 2005;23:901-44. Review.
PMID: 15771589

The role of scavenger receptors in pathogen recognition and innate immunity.
Mukhopadhyay S, Gordon S.
Immunobiology. 2004;209(1-2):39-49. Review.
PMID: 15481139

Scavenger receptors in innate immunity.
Peiser L, Mukhopadhyay S, Gordon S.
Curr Opin Immunol. 2002 Feb;14(1):123-8. Review.
PMID: 11790542

Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. Hu X, Chen J, Wang L, Ivashkiv LB.
J Leukoc Biol. 2007 Aug;82(2):237-43. Epub 2007 May 14. Review.
PMID: 17502339

The glutamate-glutamine cycle as an inducible, protective face of macrophage activation.
Gras G, Porcheray F, Samah B, Leone C.
J Leukoc Biol. 2006 Nov;80(5):1067-75. Epub 2006 Aug 15. Review.
PMID: 16912070

The molecular basis of macrophage fusion.
Helming L, Gordon S.
Immunobiology. 2007;212(9-10):785-93. Epub 2007 Nov 9. Review.
PMID: 18086379

Receptor tyrosine kinases and the regulation of macrophage activation.
Correll PH, Morrison AC, Lutz MA.
J Leukoc Biol. 2004 May;75(5):731-7. Epub 2004 Jan 14. Review. No abstract available.
PMID: 14726496

Macrophage receptors implicated in the "adaptive" form of innate immunity.
Bowdish DM, Loffredo MS, Mukhopadhyay S, Mantovani A, Gordon S.
Microbes Infect. 2007 Nov-Dec;9(14-15):1680-7. Epub 2007 Sep 14. Review.
PMID: 18023392

Macrophage scavenger receptors and host-derived ligands.
Plüddemann A, Neyen C, Gordon S.
Methods. 2007 Nov;43(3):207-17. Review.
PMID: 17920517
Related Articles

The interaction of macrophage receptors with bacterial ligands.
Plüddemann A, Mukhopadhyay S, Gordon S.
Expert Rev Mol Med. 2006 Nov 22;8(28):1-25. Review.
PMID: 17118220

Macrophage and Disease

Macrophage activation syndrome in juvenile systemic lupus erythematosus: an under-recognized complication?
Pringe A, Trail L, Ruperto N, Buoncompagni A, Loy A, Breda L, Martini A, Ravelli A.
Lupus. 2007;16(8):587-92. Review.
PMID: 17711893

Macrophage activation syndrome in juvenile idiopathic arthritis.
Cortis E, Insalaco A.
Acta Paediatr Suppl. 2006 Jul;95(452):38-41. Review.
PMID: 16801165

Macrophage activation syndrome and other systemic inflammatory conditions after BMT.
Sreedharan A, Bowyer S, Wallace CA, Robertson MJ, Schmidt K, Woolfrey AE, Nelson RP Jr.
Bone Marrow Transplant. 2006 Apr;37(7):629-34. Review.
PMID: 16501594

Tumor immunity: a balancing act between T cell activation, macrophage activation and tumor-induced immune suppression.
Sinha P, Clements VK, Miller S, Ostrand-Rosenberg S.
Cancer Immunol Immunother. 2005 Nov;54(11):1137-42. Epub 2005 May 5. Review.
PMID: 15877228

Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture.
Boyle JJ.
Curr Vasc Pharmacol. 2005 Jan;3(1):63-8. Review.
PMID: 15638783

Macrophage activation syndrome--what's in a name!
Ramanan AV, Schneider R.
J Rheumatol. 2003 Dec;30(12):2513-6. Review. No abstract available.
PMID: 14719185

Regulation of macrophage activation.
Ma J, Chen T, Mandelin J, Ceponis A, Miller NE, Hukkanen M, Ma GF, Konttinen YT.
Cell Mol Life Sci. 2003 Nov;60(11):2334-46. Review.
PMID: 14625680

CSF-1 as a regulator of macrophage activation and immune responses.
Sweet MJ, Hume DA.
Arch Immunol Ther Exp (Warsz). 2003;51(3):169-77. Review.
PMID: 12894871
Related Articles

The many faces of macrophage activation.
Mosser DM.
J Leukoc Biol. 2003 Feb;73(2):209-12. Review. No abstract available.
PMID: 12554797
Related Articles

A potential role of macrophage activation in the treatment of cancer.
Klimp AH, de Vries EG, Scherphof GL, Daemen T.
Crit Rev Oncol Hematol. 2002 Nov;44(2):143-61. Review.
PMID: 12413632
Related Articles

Macrophage polarization in tumour progression.
Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P, Mantovani A.
Semin Cancer Biol. 2008 Oct;18(5):349-55. Epub 2008 Mar 26. Review.
PMID: 18467122

Cancer related inflammation: the macrophage connection.
Sica A, Allavena P, Mantovani A.
Cancer Lett. 2008 Aug 28;267(2):204-15. Epub 2008 Apr 29. Review.
PMID: 18448242

Pathophysiology of tumor-associated macrophages.
Yuan A, Chen JJ, Yang PC.
Adv Clin Chem. 2008;45:199-223. Review.
PMID: 18429498

Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients.
Iwamoto T, Okamoto H, Toyama Y, Momohara S.
FEBS J. 2008 Sep;275(18):4448-55. Epub 2008 Jul 24. Review.
PMID: 18662305

Molecular aspects of rheumatoid arthritis: role of transcription factors.
Okamoto H, Cujec TP, Yamanaka H, Kamatani N.
FEBS J. 2008 Sep;275(18):4463-70. Epub 2008 Jul 24. Review.
PMID: 18662303

Recognition and management of macrophage activation syndrome in juvenile arthritis.
Kelly A, Ramanan AV.
Curr Opin Rheumatol. 2007 Sep;19(5):477-81. Review.
PMID: 17762614

Regulation of macrophage activation in alcoholic liver disease.
Thakur V, McMullen MR, Pritchard MT, Nagy LE.
J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S53-6. Review.
PMID: 17567466

Innate immunity, macrophage activation, and atherosclerosis.
Yan ZQ, Hansson GK.
Immunol Rev. 2007 Oct;219:187-203. Review.
PMID: 17850490

Therapeutic targets in inflammatory disease.
Hume DA, Fairlie DP.
Curr Med Chem. 2005;12(25):2925-9. Review.
PMID: 16378495