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Review of Macrophage Biology
These freely accessible resources relate mainly to macrophages and immunology and are intended for professional colleagues. They require a good general knowledge of cellular biology to interpret.
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 Cellular Responses to Immunostimulatory DNA
Author: Tara Roberts
Supervisors: Kate Stacey, Matt Sweet and David Hume
Institute for Molecular Bioscience The University of Queensland, St. Lucia Q4072, Australia
PhD thesis
Abstract:
Cells of the innate and adaptive immune systems respond to the presence of foreign DNA. Bacterial DNA is recognised by the immune system due to the presence of unmethylated CG dinucleotides within particular sequence contexts. These activating sequences are generally known as CpG (Cytosine-phosphate-Guanine) motifs. In response to the presence of CpG motifs macrophages, DCs and B-cells produce pro-inflammatory cytokines such as TNFa, IL-6 and IL-12, up-regulate co-stimulatory molecules and have an increased resistance to apoptosis. The immunostimulatory properties of bacterial DNA can be mimicked by synthetic oligonucleotides (ODN) containing CpG motifs. Other motifs in DNA also can modulate the function of the immune system - these include inhibitory motifs and oligo [dG] motifs. This thesis focuses on elucidating the mechanisms responsible for the actions of immunomodulatory DNA, primarily CpG DNA.
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How do you see CG?
Aderem A, Hume DA.
Institute for Systems Biology, Seattle, WA, USA. aderem@systemsbiology.org
Cell. 2000 Dec 22;103(7):993-6.
Abstract:
The mammalian immune response to microbial pathogens relies on both innate and adaptive components.
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Interferon-gamma: an overview of signals, mechanisms and functions.
Schroder K, Hertzog PJ, Ravasi T, Hume DA.
Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane 4072, Australia. D.Hume@imb.uq.edu.au
J Leukoc Biol. 2004 Feb;75(2):163-89. Epub 2003 Oct 02.
Abstract:
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes.
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Origins and functions of phagocytes in the embryo.
Lichanska AM, Hume DA.
Departments of Medical Genetics and Ophthalmology, Queen's University of Belfast, Belfast, United Kingdom.
Exp Hematol. 2000 Jun;28(6):601-11.
Abstract:
To review the data on the origins, phenotype, and function of embryonic phagocytes that has accumulated over past decade.
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CSF-1 as a regulator of macrophage activation and immune responses.
Sweet MJ, Hume DA.
CRC for Chronic Inflammatory Diseases, Institute for Molecular Bioscience and Department of Microbiology/Parasitology, University of Queensland, Qld 4072, Australia. m.sweet@imb.uq.edu.au
Arch Immunol Ther Exp (Warsz). 2003;51(3):169-77.
Abstract:
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases.
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The biology of macrophages.
R. Tedjo Sasmono & David A. Hume
Institute for Molecular Bioscience
The University of Queensland,
St. Lucia Q4072, Australia
In "The Innate Immune Response to Infection". S.Kaufmann, S.Gordon & R.Medzhitov. Eds. Am. Society for Microbiology Press. pp71-94
Abstract:
Macrophages are much more than the big eaters implied by their name.
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Structure, function, and regulation of tartrate-resistant acid phosphatase.
Oddie GW, Schenk G, Angel NZ, Walsh N, Guddat LW, de Jersey J, Cassady AI, Hamilton SE, Hume DA.
Department of Biochemistry, Department of Microbiology and Parasitology and Institute for Molecular Bioscience, University of Queensland, Australia.
Bone. 2000 Nov;27(5):575-84.
Abstract:
The tartrate-resistant acid phosphatases (TRAPs) are a class of metalloenzymes that catalyze the hydrolysis of various phosphate esters and anhydrides under acidic reaction conditions.
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A guide to the mammalian genome.
Yasushi Okazaki and David A. Hume
Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan; Institute for Molecular Bioscience, University of Queensland, Brisbane, Q4072, Australia.
Genome Research 13:1267-1272, 2003
Abstract:
The rapid completion and public release of the genome sequences of mouse and human has led to a down-grading of the number of "genes" predicted in the mammalian genome to the region of 30,000 (Mouse Genome Sequencing Consortium, Waterston et al. 2002).
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The actions of bacterial DNA on murine macrophages.
Sester DP, Stacey KJ, Sweet MJ, Beasley SJ, Cronau SL, Hume DA.
Centre for Molecular and Cellular Biology, and Department of Microbiology, University of Queensland, Australia.
J Leukoc Biol. 1999 Oct;66(4):542-8.
Abstract:
Murine macrophages are able to distinguish bacterial from mammalian DNA.
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S100A8: emerging functions and regulation.
Passey RJ, Xu K, Hume DA, Geczy CL.
School of Pathology, University of New South Wales, Sydney, Australia.
J Leukoc Biol. 1999 Oct;66(4):549-56.
Abstract:
The functional importance of members of the S100 Ca2+-binding protein family is becoming apparent.
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The mononuclear phagocyte system revisited.
David A. Hume, Ian L. Ross, S. Roy Himes, R. Tedjo Sasmono, Christine A. Wells,
and Timothy Ravasi.
Institute for Molecular Bioscience, University of Queensland, Australia
J. Leukoc. Biol. 72: 621-627; 2002.
Abstract:
The mononucear phagocyte system (MPS) was defined as a family of cells comprising bone marrow progenitors, blood monocytes and tissue macrophages.
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